Dantrolene and ‘ecstasy’ overdose

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Role of dantrolene in the management of the acute toxic effects of Ecstasy (MDMA).

Editor—The use of dantrolene in the management of hyperthermia for acute ‘Ecstasy’ (3,4-methylenedioxymetamphetamine, MDMA) toxicity has been recently reviewed by Hall and Hendry. We would like to confirm the efficacy of dantrolene after a recent case that presented to our emergency department. A 21-yr-old male presented after collapse with, GCS 4/15, generalized rigidity, tachycardia (160 min)...

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Malignant hyperthermia is a pharmacogenic disease and is manifest by a hypermetabolic crisis with tachycardia, ventricular ectopy, metabolic acidosis, and a rapid rise in body temperature. "Ecstasy", 3,4-methylenedioxymethamphetamine (MDMA), is a semisynthetic amphetamine, the recreational use of which has increased in recent years. Severe reactions to MDMA have been noted in the past, includin...

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ژورنال

عنوان ژورنال: Anaesthesia

سال: 2007

ISSN: 0003-2409,1365-2044

DOI: 10.1111/j.1365-2044.1993.tb06889.x